Digital transformation presents unprecedented opportunities as an enabling tool for economic growth and social inclusion. It can help strengthen linkages between sectors in economies with high levels of informality, such as in Southern countries of the Mediterranean, and it provides smaller companies the chance to expand their markets. However, digitalization can also deepen existing gaps by generating more significant exclusion and distributive inequity. Therefore, comprehensive policies and capacity-building programs appear to be essential to improve the population’s digital skills and to increase women’s participation and inclusion in innovation activities and trade process optimization.