INNOMED-UP “Promoting UPcycling in Circular Economy through INNovation and education for creative industries in MEDiterranean cities” project is coming to its final stage. In the era of digital and green transition, we discovered that cities deal with a great problem regarding waste management, which demands direct and efficient solutions. Therefore, the main goal of this innovative research program was to articulate a revitalization strategy for the Mediterranean cities, by utilizing the productive and creative networks and interconnecting them with the contemporary and essential circular economy practices.