This policy paper examines the significance of Cultural and Creative Industries (CCIs) in Egypt, Lebanon, and Tunisia and proposes strategies to build an enabling environment for entrepreneurs active in the underlying sectors. Highlighting the growth potential of CCIs, the paper identifies main challenges faced by creative entrepreneurs and provides policy recommendations at both the national and European Union levels. By fostering collaboration, strengthening intellectual property rights, and supporting independent workers, countries will be able to unlock the untapped potential of CCIs and promote sustainable development in the Southern Mediterranean region.