By 2050, food imbalance in EU-MPC is forecast to reach 60%. Sustainable water resources management is closely related to food security as 70% of global freshwater withdrawals are driven by agriculture. Energy plays a key role in producing/distributing food as well as in extracting/treating/supplying water. Climate projections to 2050 reflect an average temperature increase of 2°C, leading to a 5–10% fall in precipitation and more frequent extreme climatic events, potentially halving agricultural production by 2100. Beyond political uncertainty, generalized economic slowdown, and macroeconomic instability, EUMPC region also needs societal adaptation to climate change through new cross-sectoral approaches to manage energy/water resources and efficiently produce more food for an increasing population. Furthermore, the recent COVID19 pandemic exposed the fragility of supply chains, the importance of localized production, and the importance of investment in and capitalization of key enabling technologies, and the need to foster vulnerable groups.